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DeviceAgent: An autonomous multimodal AI agent for flexible bioelectronics
Jaeyong Lee1,2, Zuwan Lin1,3,2, Wenbo Wang1,3,2
1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Boston, MA, USA.
Biorxiv : the Preprint Server for Biology
|November 24, 2025
Summary
DeviceAgent, an AI system using large language models (LLMs) and vision-language models (VLMs), streamlines flexible bioelectronics research. It automates design, fabrication, inspection, and analysis, enhancing AI-scientist collaboration.
Area of Science:
- Bioelectronics
- Artificial Intelligence
- Materials Science
Background:
- Flexible bioelectronics development is complex, requiring specialized expertise and limiting scalability.
- Current research faces challenges in automation, adaptability, and accessibility.
- Integrating AI tools can potentially overcome these limitations.
Purpose of the Study:
- To introduce DeviceAgent, an autonomous multimodal AI agent for bioelectronics research.
- To demonstrate DeviceAgent's capabilities in automating key experimental pipeline stages.
- To establish a scalable paradigm for AI-scientist collaboration in nanofabrication.
Main Methods:
- DeviceAgent integrates large language models (LLMs), vision-language models (VLMs), and computational tools.
- A multimodal context memory system supports end-to-end experimental pipeline tasks.
- The system allows human oversight at critical decision points.
Main Results:
- DeviceAgent autonomously generates bioelectronic layouts and fabrication protocols.
- It identifies microscopic defects using visual reasoning and analyzes electrophysiological recordings.
- The AI agent demonstrated capabilities in developing stretchable mesh electronics for cardiomyocytes.
Conclusions:
- DeviceAgent offers a scalable and accessible framework for AI-driven bioelectronics research.
- The integration of LLMs and VLMs enhances zero/few-shot generalization and contextual learning.
- This AI-scientist collaboration paradigm accelerates innovation in nanofabrication and bioelectronic device development.

