Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jan 10, 2026

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

3D Hybrid Bioprinting for Complex Multi-Tissue Engineering.

Hossein Vahid Alizadeh¹, Andrea S Flores Pérez², Tomohiro Uno¹

¹Department of Orthopaedic Surgery, Stanford University, Stanford, USA.

Biorxiv : the Preprint Server for Biology

|November 24, 2025

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Laser and Energy-Based Devices in Aesthetic Practice: A 10-Year Single-Surgeon Review of Treatments, Complications, and Same-Practice Surgical Crossover.

Aesthetic surgery journal. Open forum·2026

Same author

Impact of multiple sclerosis disease-modifying therapies on chronic lesion tissue expansion.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026

Same author

A Recombinant OMV-Based Vaccine Elicits Potent Protective Immunity Against <i>Pseudomonas aeruginosa</i>.

Vaccines·2026

Same author

Long-term effects of a bony mucoperiosteal flap on bone preservation in bony impacted upper third molar surgery: a prospective exploratory study.

BMC oral health·2026

Same author

Enhanced pollutants removal and contributions analysis of near-natural floating bed coupling with microbial fuel cell.

Journal of environmental sciences (China)·2026

Same author

An Artificial Intelligence based model for predicting long-term all-cause mortality after acute Myocardial Infarction (the AIMI model).

European heart journal. Digital health·2026

Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026

Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026

Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026

Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026

Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026

Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026

See all related articles

This summary is machine-generated.

This study introduces a 3D hybrid bioprinting platform for advanced tissue engineering. The novel approach creates robust, multifunctional constructs with enhanced mechanical strength for complex tissue applications.

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Conventional 3D bioprinting struggles to integrate soft and rigid materials for complex tissue constructs.
Existing methods limit the fabrication of multifunctional, mechanically robust engineered tissues.

Purpose of the Study:

To introduce a 3D hybrid bioprinting approach using the Hybprinter platform.
To demonstrate the fabrication of multi-material, multifunctional tissue constructs with enhanced properties.

Main Methods:

Utilized a novel Hybprinter platform integrating multiple 3D printing modules.
Employed a continuous bioprinting process with multiple soft and hard biomaterials.
Fabricated multi-hydrogel hybrid constructs with vascularization, mechanical robustness, and suturability.

Keywords:

biomaterials bioprinting multi-material biofabrication musculoskeletal therapeutics orthopedic grafts tissue engineering

More Related Videos

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Published on: June 30, 2023

Related Experiment Videos

Last Updated: Jan 10, 2026

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Author Spotlight: Understanding Chronic Lung Diseases Using 3D Printed Phototunable Hydrogels

Published on: June 30, 2023

Main Results:

Achieved over a 1000-fold increase in mechanical strength compared to hydrogel-only constructs.
Demonstrated enhanced osteogenic and chondrogenic differentiation in cell-laden constructs.
Successfully integrated multi-material components, gradient properties, and bioactive agents.

Conclusions:

The 3D hybrid bioprinting approach offers robust biocompatibility and broad tissue engineering potential.
This versatile platform advances complex tissue engineering for patient-specific, organ-on-demand applications.
The technology enables the creation of mechanically strong, suturable, and multifunctional tissue constructs.