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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
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DLL3-targeted immunoPET and radioimmunotherapy ligands
1Department of Radiology and Imaging Sciences, Emory University Atlanta, Georgia 30322, The United States.
American Journal of Nuclear Medicine and Molecular Imaging
|November 24, 2025
Abstract
None:
DLL3 is overexpressed on the cell surface of NENs, such as SCLC and NEPC, but notably restricted to cytoplasm with low expression levels in normal adult human tissues. Several radioligands have been developed by targeting DLL3 for immunoPET or radioimmunotherapy use. These ligands hold great promise for mapping the heterogeneous DLL3 expression in neuroendocrine tumors and guiding the DLL3-directed therapeutic strategies.
