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Primary Central Nervous System (CNS) Post-Transplant Lymphoproliferative Disorder: A Case Report.
Jared M Taitt1, Christopher Lees1, George N Tran2,1
1Internal Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Cureus
|November 24, 2025
Summary
Post-transplant lymphoproliferative disorder (PTLD) is a common malignancy after solid organ transplantation (SOT). This case highlights rare primary central nervous system PTLD occurring 15 years post-renal transplant, emphasizing ongoing patient monitoring.
Area of Science:
- Oncology
- Transplantation Medicine
- Neurology
Background:
- Post-transplant lymphoproliferative disorder (PTLD) is the most frequent non-dermatologic malignancy post-solid organ transplantation (SOT).
- PTLD typically manifests within five years of SOT, with central nervous system (CNS) involvement being infrequent.
- Early diagnosis and management are crucial for patient outcomes.
Keywords:
ebv ptldimmunosuppression complicationspost transplant lymphoproliferative disorderpost-renal transplant complicationsrare cause of altered mental statusMore Related Videos
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