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Updated: May 7, 2026

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Determining the Functional Status of the Corticospinal Tract Within One Week of Stroke

Published on: February 22, 2020

Associations between structural injury and task-based corticomuscular connectivity after stroke.

Rachana Gangwani^1,2, Jasper I Mark^1,2, Benjamin Y Huang³

¹Human Movement Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Frontiers in Neurology

|November 24, 2025

Summary

Stroke alters brain pathways, affecting behavior. This study found specific links between corticospinal tract (CST) injury/integrity and corticomuscular coherence (CMC) during movement in stroke survivors.

Keywords:

corticomuscular coherence (CMC)electroencephalography (EEG)electromyography stroke structural injury task-based corticomuscular connectivity

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Last Updated: May 7, 2026

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The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

Published on: May 2, 2021

Area of Science:

Neuroscience
Rehabilitation Medicine
Biomedical Engineering

Background:

Stroke damages neural pathways, disrupting communication and causing behavioral deficits.
Understanding structure-function relationships is crucial for neurorehabilitation.
Previous research focused on resting-state connectivity; task-based connectivity offers new insights.

Purpose of the Study:

To examine the relationship between structural injury and task-based functional connectivity (corticomuscular coherence; CMC) in stroke survivors.
To investigate how corticospinal tract (CST) integrity and injury relate to CMC during a grip task.

Main Methods:

Simultaneous electroencephalography (EEG) and electromyography (EMG) were recorded during a grip task in subacute stroke patients.
Corticospinal tract (CST) injury and integrity were assessed using structural and diffusion-weighted imaging.
Corticomuscular coherence (CMC) was computed in relevant frequency bands (delta, low beta, high beta).

Main Results:

No significant structure-function associations were found in the overall group.
In subgroups, greater CST injury correlated with higher high-beta CMC between supplementary motor area and extensor digitorum.
Higher CST integrity positively related to low-beta CMC between primary motor cortex and biceps.

Conclusions:

Subgroup-specific findings highlight the complexity of structure-function relationships post-stroke.
Task-based CMC in motor-relevant bands is modulated by CST microstructure, suggesting neuroplastic changes.
These insights can inform targeted rehabilitation strategies for optimizing stroke recovery.