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Self-supervised learning and transformer-based technologies in breast cancer imaging.

Lulu Wang1,2

  • 1Department of Engineering, Reykjavik University, Reykjavik, Iceland.

Frontiers in Radiology
|November 24, 2025
PubMed
Summary

Recent advancements in artificial intelligence (AI), specifically self-supervised learning (SSL) and transformer models, are enhancing breast cancer imaging analysis. These AI techniques improve lesion detection, segmentation, and classification, paving the way for more accurate diagnoses.

Keywords:
artificial intelligencebreast cancermedical imagingself-supervised learningtransformers

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Oncology

Background:

  • Breast cancer is a leading global malignancy in women.
  • Medical imaging is crucial for early detection, diagnosis, and treatment planning.
  • Artificial intelligence (AI) offers novel approaches to breast image analysis.

Purpose of the Study:

  • To provide a comprehensive overview of recent developments in AI for breast imaging.
  • To highlight the application of self-supervised learning (SSL) and transformer models in breast lesion analysis.
  • To discuss the advantages, limitations, and future directions of these AI technologies.

Main Methods:

  • Review of recent studies utilizing self-supervised learning (SSL) for breast image analysis.
  • Analysis of transformer-based architectures, including Vision Transformers, for capturing global contextual information in breast images.
  • Examination of AI models for breast lesion segmentation, detection, and classification.

Main Results:

  • SSL demonstrates label-efficient strategies and strong performance in breast image analysis.
  • Transformer models effectively capture long-range dependencies and global context, complementing traditional methods.
  • Representative studies showcase advancements in AI-driven breast lesion segmentation, detection, and classification.

Conclusions:

  • AI, particularly SSL and transformer models, shows significant promise for improving breast cancer imaging.
  • Clinical translation requires multi-institutional datasets, external validation, and interpretable AI models.
  • Future research should focus on generalizability, real-world performance validation, and clinician trust for safe deployment.