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Directed evolution of an m6A eraser for site-selective epitranscriptome editing.

Huiqing Zhou1, Chuan-Hui Wang1

  • 1Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA.

Research Square
|November 24, 2025
PubMed
Summary

Researchers developed a new method to engineer better RNA demethylase enzymes. This led to FTO-818, an enzyme with 13x higher efficiency, enabling precise control over N6-methyladenosine (m6A) modifications in cells.

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