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Factors Related to Abnormal Endoscopic and Histologic Findings on Upper Gastrointestinal Endoscopy in Children
1Department of Pediatrics, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Korea.
Insights
Most children with dyspepsia show abnormal endoscopic findings. Routine biopsies during upper endoscopy are crucial for accurate diagnosis and identifying factors like age and eating habits influencing these results.
Area of Science:
- Pediatric Gastroenterology
- Diagnostic Endoscopy
Background:
- Upper gastrointestinal endoscopy is vital for diagnosing pediatric gastrointestinal symptoms.
- Pathological descriptions from endoscopy aid in understanding underlying conditions.
Purpose of the Study:
- To identify abnormal endoscopic and histological findings in children undergoing upper endoscopy.
- To evaluate factors associated with these abnormal findings in pediatric patients.
Main Methods:
- Retrospective analysis of medical records for 120 pediatric patients (<18 years) who underwent upper endoscopy from January 2017 to June 2022.
- Biopsies and rapid urease tests were performed during endoscopy.
Main Results:
- Abnormal endoscopic and histological findings were present in 71.7% and 92.5% of patients, respectively.
- Common findings included erythema (endoscopic) and chronic gastritis (histological).
- Significant predictors of endoscopic abnormalities included age ≥12 years, poor eating habits, melena, and nausea.
Conclusions:
- The majority of children with dyspepsia exhibit endoscopic abnormalities.
- Routine biopsies during endoscopy are essential for comprehensive evaluation in pediatric patients.
- Predictors for endoscopic findings in children were identified, aiding in targeted investigations.
Purpose:
Upper gastrointestinal endoscopy is important in evaluating gastrointestinal symptoms and providing pathological descriptions. In this study, abnormal endoscopic and histological findings were identified in children, and the factors related to these findings were evaluated.
Methods:
We retrospectively analyzed the medical records of patients aged <18 years who underwent upper endoscopies between January 2017 and June 2022. While performing endoscopy, biopsies were taken, and the rapid urease test was performed simultaneously.
Results:
The endoscopic and histological findings were abnormal for 86 of (71.7%) and 111 (92.5%) of the 120 patients, respectively. Only four patients had normal endoscopic and histological findings. The most common endoscopic and histological findings were erythema (35%) and chronic gastritis (53.5%), respectively. Age ≥12 years (odds ratio [OR], 2.55; 95% confidence interval [CI], 1.21-6.68; p=0.033), poor eating habits (OR, 0.30; 95% CI, 0.10-0.88; p=0.029), melena (OR, 3.45; 95% CI, 1.22-6.42 p=0.043), and nausea (OR, 0.31; 95% CI, 0.13-0.74 p=0.009) were significant factors related to endoscopic abnormalities in the multivariate analysis. More frequent Helicobacter pylori infection was observed in patients with atrophy and intestinal metaplasia than in those with other histological abnormalities.
Conclusion:
Most children with dyspepsia gave endoscopic abnormalities, and routine biopsies are important when performing endoscopy. We identified predictors of endoscopic findings.
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