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Remnant Cholesterol is Associated with Blood Pressure Control in US Adults with Hypertension: NHANES 2007-2018

Siqin Feng1, Su Zou2, Muyun Tang3

  • 1Division of Cardiology, Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Vascular Health and Risk Management
|November 24, 2025
PubMed

Insights

Elevated remnant cholesterol levels are linked to poorer blood pressure control in the general US population. Managing remnant cholesterol may improve hypertension management, especially in high-risk individuals.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Public Health

Background:

  • High blood pressure is a significant risk factor for cardiovascular and renal diseases.
  • Lipid metabolism disorders, including remnant cholesterol, may influence blood pressure via mechanisms like endothelial inflammation.
  • Remnant cholesterol, derived from triglyceride-rich lipoproteins, is implicated in atherosclerosis and metabolic disorders.

Purpose of the Study:

  • To investigate the association between remnant cholesterol and blood pressure control.
  • To analyze this relationship within the general US population.

Main Methods:

  • Utilized data from 3915 participants with self-reported hypertension from the NHANES (2007-2018).
  • Collected demographic, behavioral, blood pressure, and blood sample data.
  • Estimated remnant cholesterol and defined hypertension control (systolic BP <140 mmHg and diastolic BP <90 mmHg).

Main Results:

  • The study included a mean age of 56.98 years, with 51.34% females.
  • 2650 participants (67.94%) achieved blood pressure control.
  • Multivariate logistic regression revealed a significant inverse association between remnant cholesterol and blood pressure control (e.g., OR=0.60, 95% CI: 0.46-0.78 after full adjustment).

Conclusions:

  • Remnant cholesterol is significantly associated with blood pressure control in the US general population.
  • Targeting remnant cholesterol through lifestyle changes or lipid-lowering therapies could be a strategy to improve hypertension management.
  • Further research may elucidate specific interventions for high-risk patients.
Abstract

Keywords:
blood pressure controlhypertensioninflammationremnant cholesterol

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