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Updated: Jan 10, 2026

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Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
Published on: January 24, 2025
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Estimating the sensitivity of non-treponemal and treponemal antibody tests in primary syphilis
Stephanie F Sweitzer1, Jane S Chen1, Mitch M Matoga2
1Division of Infectious Diseases, Department of Internal Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Medrxiv : the Preprint Server for Health Sciences
|November 24, 2025
Abstract:
Among patients with primary syphilis, sensitivity of TRUST was 55% (6/11) compared to darkfield microscopy (DFM) and 60% (9/15) compared to Treponema pallidum PCR. Sensitivity of RPR was 78% (38/49) and 93% (43/46), respectively. TPPA had a sensitivity of 95% (41/43) compared to DFM and 96% (43/45) compared to PCR.

