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Are Endoscopic Sinus Surgery Complication Rates Improving Over Time and With the Adoption of Image Guidance?
Medrxiv : the Preprint Server for Health Sciences
|November 24, 2025
Summary
Endoscopic sinus surgery (ESS) complications remain low, but epistaxis rates are increasing. Intraoperative navigation systems (IGS) use is linked to reduced CSF leak risk but higher epistaxis rates.
Area of Science:
- Otolaryngology
- Surgical Innovation
- Patient Safety
Background:
- Endoscopic sinus surgery (ESS) is a common treatment for chronic rhinosinusitis (CRS).
- Established complication rates for ESS are often cited in literature and patient counseling.
- Advancements in surgical techniques and technology may influence modern complication rates.
Purpose of the Study:
- To evaluate contemporary complication rates following ESS.
- To assess trends in complications and intraoperative navigation system (IGS) use over time.
- To compare complication rates across different age groups.
Main Methods:
- A retrospective analysis of the TriNetX Research Network (2010-2023) was performed.
- Data included ESS complications such as CSF leak, orbital injury, and epistaxis.
- Complication rates and IGS trends were analyzed across two time periods (2010-2016 vs. 2017-2023) and age groups (pediatric, adolescent, adult).
Main Results:
- Major complications (CSF leak, orbital injury) rates were similar or improved compared to prior reports.
- Epistaxis and other perioperative complications exceeded 1%, indicating a need for attention.
- IGS use increased over time and was associated with lower CSF leak rates (0.8% vs. 0.95%) but higher epistaxis rates (2.5% vs. 2.1%).
- CSF leak rates were higher in patients under 18, while adults experienced higher epistaxis rates.
Conclusions:
- ESS complications remain low, but rising epistaxis rates warrant attention.
- Increased perioperative complications may be linked to worsening population health.
- IGS use is associated with a decreased risk of CSF leak.
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