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Updated: Jan 10, 2026
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Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
Published on: March 1, 2019
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CARINH, an Interferon-Induced LncRNA in Cancer and Inflammation.
Morgane Gourvest1, Coen van Solingen1
1Department of Medicine, Cardiovascular Research Center, New York University Grossman School of Medicine, New York, NY 10016, USA.
Non-Coding RNA
|November 24, 2025
Summary
CARINH, a conserved long noncoding RNA, plays a key role in innate immunity and cancer. Its regulation impacts antiviral defense, immune homeostasis, and tumor suppression, offering therapeutic potential.
Area of Science:
- Molecular Biology
- Immunology
- Oncology
Background:
- CARINH is a conserved long noncoding RNA with roles in innate immunity and cancer.
- It is stimulated by interferons and viral infections, crucial for antiviral defense.
- Dysregulation is linked to autoimmune diseases and cancer progression.
Purpose of the Study:
- To review the pivotal function of CARINH in modulating interferon responses and cancer development.
- To explore the molecular pathways regulating CARINH expression and its diverse roles.
- To evaluate CARINH as a potential biomarker and therapeutic target.
Main Methods:
- Literature review focusing on CARINH's function in immunity and cancer.
- Analysis of molecular pathways regulating CARINH expression.
- Investigation of CARINH's role in interferon response and tumor suppression.
Main Results:
- CARINH is a key regulator of interferon responses and antiviral defense.
- Its dysregulation is implicated in autoimmune disorders and cancer.
- Alterations in CARINH expression impact immune homeostasis and tumor suppression.
Conclusions:
- CARINH is a significant molecule linking innate immunity and cancer development.
- Understanding its regulatory pathways is crucial for therapeutic advancements.
- CARINH holds promise as a biomarker and therapeutic target in medicine.
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