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Published on: August 12, 2019
A Tandem Catalytic Approach for the Synthesis of Aminophenones Using an Amine-Integrated Bifunctional Cobalt-NHC
Biswaranjan Boity1, Arpita Sahoo1, Arnab Rit1
1Department of Chemistry, Indian Institute of Technology Madras, Chennai-600036, India.
None:
We report herein a bifunctional CoIII-NHC complex promoted unique protocol for generating diverse aminophenones from oxindole using aliphatic alcohols and aerial O2 under mild conditions. The unparalleled dual functionality of this cobalt-catalyst enables the target product formation through a one-pot, sequential hydrogen autotransfer and oxidative transformation pathway, as established by in-depth mechanistic studies. Finally, the synthetic utility of the resulting aminophenones is highlighted by their transformation into various important heterocyclic scaffolds, including quinazoline, quinolinone, oxazine, and quinoline.
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