Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
06:15

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

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Optical coherence tomography angiography in evaluating the response of ocular surface squamous neoplasia to topical

Hamidreza Ghanbari1, Ahmad Masoumi2, Mahsan Samadi1

  • 1Department of Ophthalmology, Farabi Eye Hospital, School of Medicine, Tehran University of Medical Sciences, Qazvin Sq, Tehran, Iran.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|November 24, 2025
PubMed
Abstract

Insights

Topical interferon α-2b (IFN-α2b) effectively treats ocular surface squamous neoplasia (OSSN). Optical coherence tomography angiography (OCTA) reveals significant decreases in superficial vessel density and diameter, indicating treatment response.

Area of Science:

  • Ophthalmology
  • Oncology
  • Medical Imaging

Background:

  • Ocular surface squamous neoplasia (OSSN) is a pre-malignant or malignant epithelial tumor.
  • Topical interferon α-2b (IFN-α2b) is a common treatment for OSSN.
  • Evaluating treatment efficacy requires monitoring tumor vascularity.

Purpose of the Study:

  • To assess changes in Optical Coherence Tomography Angiography (OCTA) parameters during topical IFN-α2b treatment for OSSN.
  • To determine if OCTA can effectively monitor treatment response in OSSN patients.

Main Methods:

  • Thirty-five OSSN patients received topical IFN-α2b.
  • Ophthalmic examinations and slit lamp photography were performed.
  • OCTA imaging captured ocular surface vasculature at baseline, during treatment, and post-resolution.
  • Superficial and deep vascular density (VD), vessel length density (VLD), and vessel diameter index (VDI) were quantified.

Main Results:

  • Mean tumor area decreased from 20.7 mm² to 15.1 mm² during treatment.
  • Superficial VD significantly decreased from 36.3% to 30.5% (P<0.05).
  • Superficial VDI significantly decreased from 1.87 to 1.74 (P<0.05).
  • No significant changes were noted in deep vascular parameters or VLD.

Conclusions:

  • OCTA is a valuable tool for evaluating vascular changes in OSSN during medical treatment.
  • Decreases in superficial VD and VDI may serve as indicators of successful response to topical IFN-α2b therapy.
Keywords:
Anterior segmentIFNOCTAOSSNOcular surface tumor

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