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THE EFFECT OF PREECLAMPSIA SEVERITY ON CHORIORETINAL MICROVASCULAR CIRCULATION: A Pilot Prospective Optical Coherence
Zeynep Özer Özcan1, Kıvanç Güngör1, Hüseyin Çağlayan Özcan2
1Departments of Ophthalmology, and.
Retina (Philadelphia, Pa.)
|November 24, 2025
Summary
Preeclampsia severity impacts the eye's microvasculature. Severe preeclampsia shows lower deep capillary plexus vessel density (DCPVD) and radial peripapillary capillary vessel density (RPCVD), with slower recovery postpartum.
Area of Science:
- Ophthalmology
- Perinatology
- Vascular Biology
Background:
- Preeclampsia is a serious pregnancy complication characterized by high blood pressure.
- Its systemic effects on microvasculature, particularly in the retina, are not fully understood.
Purpose of the Study:
- To prospectively evaluate the effect of preeclampsia severity on chorioretinal microvasculature.
- To utilize optical coherence tomography angiography (OCT-A) for detailed microvascular assessment.
Main Methods:
- Sixty-six patients were divided into mild and severe preeclampsia groups.
- OCT-A imaging was performed pre-delivery, 2 days postpartum, and 6 weeks postpartum.
- Chorioretinal microvascular density parameters were compared and correlated with blood pressure.
Main Results:
- Deep capillary plexus vessel density (DCPVD) and radial peripapillary capillary vessel density (RPCVD) increased postpartum in both groups.
- Severe preeclampsia patients had significantly lower DCPVD and RPCVD before delivery and early postpartum compared to mild cases.
- DCPVD and RPCVD showed significant negative correlations with systemic blood pressure.
Conclusions:
- Preeclampsia severity significantly affects chorioretinal microvascular density.
- DCPVD and RPCVD are inversely related to blood pressure.
- While retinal microvasculature improves post-delivery, severe preeclampsia leads to a more prolonged vascular impairment.
