Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

4.5K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
4.5K
Redox Reactions01:27

Redox Reactions

856
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
856
Redox Reactions01:24

Redox Reactions

58.1K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
58.1K
Radical Autoxidation01:20

Radical Autoxidation

3.0K
The oxidation of an organic compound in the presence of air or oxygen is called autoxidation. For example, cumene reacts with oxygen to form hydroperoxide. Autoxidation involves initiation, propagation, and termination steps. Many organic compounds are susceptible to autoxidation—especially ethers in the presence of oxygen, which form hydroperoxides. Even though this reaction is slow, old ether bottles contain small amounts of peroxide, which leads to laboratory explosions during ether...
3.0K
Redox Equilibria: Overview01:23

Redox Equilibria: Overview

1.5K
A reduction-oxidation reaction is commonly called a redox reaction. In a redox reaction, electrons are transferred from one species to another rather than being shared between or among atoms. The reducing agent or reductant is the species that loses electrons and gets oxidized in the process. The species that gains electrons and gets reduced in the process is the oxidizing agent or oxidant. Redox reactions are represented as two separate equations called half-reactions, where one equation...
1.5K
Peroxisomes01:24

Peroxisomes

19.9K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
19.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weather-Resistant Thermoresponsive UV-Curable Smart Window Composites Based on Paraffin Particles.

ACS applied materials & interfaces·2026
Same author

Ending Lassa neglect: the urgent case for a licensed vaccine.

Annals of medicine and surgery (2012)·2026
Same author

ThinkAI: A Natural Language Processing-based Intelligent framework for Mental Health.

Big data·2026
Same author

RETRACTED: Ullah et al. Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications. <i>Molecules</i> 2022, <i>27</i>, 6631.

Molecules (Basel, Switzerland)·2026
Same author

A Mussel-Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Sustainable N/S co-doped porous carbon from waste lemon peels for high-performance zinc-ion hybrid supercapacitors.

Nanoscale·2025

Related Experiment Video

Updated: Jan 10, 2026

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines
05:16

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines

Published on: January 19, 2024

6.4K

The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications.

Jose Bolaños-Cardet1,2, Belén Pepió-Tárrega1, Javier Saiz-Poseu1

  • 1Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Barcelona, 08193, Spain.

Angewandte Chemie (International Ed. in English)
|November 25, 2025
PubMed
Summary
This summary is machine-generated.

Polyphenols offer dual antioxidant and reactive oxygen species (ROS) generation capabilities for biomedical materials. Challenges in clinical translation remain, but AI integration may accelerate future polyphenol-based therapeutic development.

Keywords:
BiomaterialsNanomedicinePolyphenolsReactive oxygen species (ROS)Redox chemistry

More Related Videos

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.2K
Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

70.9K

Related Experiment Videos

Last Updated: Jan 10, 2026

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines
05:16

Author Spotlight: High-Throughput Measurement of Intracellular ROS Levels in Hepatocellular Lines

Published on: January 19, 2024

6.4K
Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

2.2K
Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

70.9K

Area of Science:

  • Biomaterials Science
  • Medicinal Chemistry
  • Nanotechnology

Background:

  • Polyphenols, especially catechols, possess unique redox properties derived from natural and industrial sources.
  • These properties enable both antioxidant effects and controlled generation of reactive oxygen species (ROS).

Purpose of the Study:

  • To review the biomedical applications of polyphenol-based materials.
  • To highlight the role of ROS modulation in therapeutic effects.
  • To discuss challenges and future directions for clinical translation.

Main Methods:

  • Literature review synthesizing current research on polyphenol-based biomedical materials.
  • Analysis of redox properties and ROS modulation mechanisms.
  • Exploration of applications in various biomedical fields.

Main Results:

  • Polyphenols are utilized in nanoparticles, hydrogels, bioadhesives, coatings, and membranes.
  • ROS modulation by polyphenols shows promise in antimicrobial strategies, cancer therapy, and tissue regeneration.
  • Significant preclinical success faces hurdles in pharmacokinetics, biosafety, and manufacturing.

Conclusions:

  • Polyphenol-based materials offer versatile biomedical potential driven by redox and ROS-modulating activities.
  • Clinical translation requires overcoming challenges in delivery, safety, and consistency.
  • Future research should focus on precise ROS control, advanced delivery, rational design, and AI integration.