Mitochondrial Nephropathy With m.5538G>A Mutation Within the tRNA-Trp Region Assessed by Mitochondrial Function
Mari Ikeda1, Toshiyuki Imasawa2, Takafumi Akanuma1,3
1Department of Nephrology, Kameda Medical Center, Chiba, Japan.
Nephrology (Carlton, Vic.)
|November 25, 2025
Summary
This study explores imeglimin for mitochondrial nephropathy (MIT-N), a kidney disease. While imeglimin reduced proteinuria, kidney function decline persisted, suggesting further research is needed for MIT-N treatment.
Area of Science:
- Nephrology
- Mitochondrial Medicine
- Pharmacology
Background:
- Mitochondrial nephropathy (MIT-N) affects over 90% of patients with urinary protein and 70% with reduced kidney function.
- Current treatments like Coenzyme Q10 show limited efficacy in MIT-N patients.
- Imeglimin, a mitochondrial function enhancer, is investigated for MIT-N.
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