Association Between Postoperative Complications and Real-Time Oxidative Stress Measurements Using Electron Spin...

Area of Science:

• Biomedical Engineering
• Surgical Oncology
• Clinical Chemistry

Background:

• Surgical stress exacerbates oxidative stress, impacting patient recovery.
• Perioperative oxidative stress monitoring offers insights for surgical management.
• Electron spin resonance (ESR) can measure oxidative stress markers in real-time.

Purpose of the Study:

• To investigate the link between perioperative oxidative stress and postoperative complications.
• To evaluate ascorbyl free radical (AFR) levels as a real-time biomarker.
• To identify factors influencing oxidative stress during the perioperative period.

Main Methods:

• Plasma ascorbyl free radical (AFR) levels, supplemented with dimethyl sulfoxide (AFR/DMSO), were measured using ESR.
• Measurements were taken preoperatively and postoperatively in patients undergoing elective surgery.
• Correlation analysis was performed between AFR/DMSO levels, surgical Apgar score, and postoperative complications.

Main Results:

• Postoperative AFR/DMSO levels were significantly lower than preoperative levels (P<0.001).
• AFR/DMSO levels positively correlated with surgical Apgar score (r=0.25, P=0.002).
• Lower AFR/DMSO levels correlated with an increased number of postoperative complications (r=-0.22, P=0.007).

Conclusions:

• ESR-based AFR/DMSO measurements serve as a sensitive, real-time indicator of oxidative stress.
• AFR/DMSO is a valuable biomarker for predicting postoperative outcomes.
• Prolonged surgery and inflammation predict reduced postoperative AFR/DMSO levels.