Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.4K
Overview
83.4K
Inflammatory Response01:28

Inflammatory Response

15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K
T Cell Types and Functions01:24

T Cell Types and Functions

2.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.1K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.6K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.6K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.6K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.7K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Interaction Between Iron Overload and Lead Exposure on Bone Metabolism.

Frontiers in bioscience (Landmark edition)·2026
Same author

Bile Canalicular Bitter Taste Receptors Inhibit β-Adrenergic Receptor-Induced Lipolysis in Steatotic Hepatocytes.

International journal of molecular sciences·2026
Same author

Inhibition of CIRBP as a Novel Strategy to Alleviate Chondrocyte Ferroptosis in Haemophilic Arthropathy.

Haemophilia : the official journal of the World Federation of Hemophilia·2025
Same author

Metallic Contaminants and Osteoporosis: a Review of the Gut-Bone Axis.

Biological trace element research·2025
Same author

Identification of Iron Overload-Associated Biomarkers in the Synovium of Haemophilic Arthropathy.

Haemophilia : the official journal of the World Federation of Hemophilia·2025
Same author

Interleukin-10 Mitigates Chondrocyte Ferroptosis Associated With Haemophilic Arthropathy via Modulation of the STAT3 Signalling Pathway.

Haemophilia : the official journal of the World Federation of Hemophilia·2025

Related Experiment Video

Updated: Jan 10, 2026

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.7K

Tuft cell-mediated pathogen sensing and inflammation resolution.

Liquan Huang1, Yuan-Yuan Peng1, Defu Yu1

  • 1College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.

Biochemical Society Transactions
|November 25, 2025
PubMed
Summary
This summary is machine-generated.

Tuft cells act as chemosensory sentinels, detecting pathogens and initiating immune responses. These versatile epithelial cells also play crucial roles in tissue repair and inflammation resolution.

Keywords:
host–pathogen interactionsimmune responseinnate immunitystem cellstaste

More Related Videos

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.9K
T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

12.3K

Related Experiment Videos

Last Updated: Jan 10, 2026

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment
09:00

Characterization of Immune Cells and Proinflammatory Mediators in the Pulmonary Environment

Published on: June 24, 2020

3.7K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.9K
T Cells Capture Bacteria by Transinfection from Dendritic Cells
11:39

T Cells Capture Bacteria by Transinfection from Dendritic Cells

Published on: January 13, 2016

12.3K

Area of Science:

  • Cell Biology
  • Immunology
  • Gastroenterology

Background:

  • Tuft cells are rare epithelial cells with unique structures and gene expression, including Pou2f3.
  • Tuft cell heterogeneity exists across and within tissues, with epigenetic and microenvironmental regulation.
  • Tuft cells can form ectopically, transdifferentiate, or dedifferentiate in response to injury.

Purpose of the Study:

  • To explore the multifaceted roles of tuft cells in chemosensation, immunity, and tissue repair.
  • To understand the regulation of tuft cell formation and gene expression.
  • To investigate the signaling pathways and effectors involved in tuft cell function.

Main Methods:

  • Literature review and synthesis of existing research on tuft cells.
  • Analysis of gene expression patterns and epigenetic regulation in tuft cells.
  • Examination of tuft cell interactions with pathogens, immune cells, and epithelial cells.

Main Results:

  • Tuft cells function as chemosensory sentinels detecting pathogens like bacteria, protists, and helminths.
  • Activated tuft cells release effectors such as IL-25, eicosanoids, acetylcholine, and ATP.
  • These effectors modulate innate immunity, epithelial cell function, and neuroimmune responses.
  • Tuft cells are vital for inflammation resolution and tissue repair processes.

Conclusions:

  • Tuft cells are critical mediators of host defense against pathogens.
  • Tuft cells orchestrate complex immune and physiological responses.
  • Further research into tuft cell signaling pathways will illuminate their roles in health and disease.