Related Experiment Video

Updated: Jan 10, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.1K

Absolute time-dependent risk of hospital-acquired venous thromboembolism in children

Maya K Raad1, Stephanie Prozora1, E Vincent S Faustino1

  • 1Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA.

Thrombosis Research
|November 25, 2025
PubMed

Insights

This study accurately predicted the absolute time-dependent risk of hospital-acquired venous thromboembolism (HA-VTE) in children. This prediction tool can help evaluate thromboprophylaxis benefits and guide future research on bleeding risk.

Area of Science:

  • Pediatric Thrombosis Research
  • Clinical Risk Prediction Modeling
  • Hospital-Acquired Conditions

Background:

  • Assessing the absolute time-dependent risk of hospital-acquired venous thromboembolism (HA-VTE) is crucial for determining the net clinical benefit of pharmacologic thromboprophylaxis in pediatric patients.
  • The existing Children's Hospital Acquired Thrombosis (CHAT) risk assessment model (RAM) identified pediatric HA-VTE risk factors but was not designed for risk prediction.
  • There is a need for a model that accurately predicts the absolute time-dependent risk of HA-VTE in hospitalized children.

Purpose of the Study:

  • To develop and validate a model for predicting the absolute time-dependent risk of HA-VTE in hospitalized children.
  • To identify key risk factors associated with the development of HA-VTE in this population.
  • To provide a tool for better risk stratification and management of HA-VTE in pediatric care.

Main Methods:

  • A single-center case-cohort study was conducted involving children aged ≤18 years admitted between 2013 and 2022.
  • Children with confirmed, symptomatic HA-VTE were identified as cases, and a 5% random sample of eligible admissions formed the subcohort.
  • Kaplan-Meier estimates and Cox regression, incorporating CHAT RAM risk factors, were used to calculate the absolute time-dependent risk of HA-VTE, with performance assessed via AUROC and AUPRC.

Main Results:

  • A total of 81 children with HA-VTE were identified from 23,287 admissions.
  • Adolescent age, limited mobility, and central venous catheter use were significantly associated with the time to HA-VTE.
  • The median absolute time-dependent risk of HA-VTE was 1.7% by day 12, with an AUROC of 0.81, indicating good predictive performance.

Conclusions:

  • The developed model accurately predicts the absolute time-dependent risk of HA-VTE in hospitalized children.
  • The findings highlight the importance of considering factors like age, mobility, and central venous catheter use in risk assessment.
  • Further research should focus on developing similar predictive models for bleeding events in pediatric patients.
Abstract

Keywords:
BleedingDeep venous thrombosisPediatricProphylaxisRisk assessment

More Related Videos

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis06:45

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis

Published on: February 10, 2023

15.8K
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
268
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
188
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
321
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
277
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
196
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
247