Instant Protection Nanospray Bandage Driven Anti-Scar Wound Healing

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Nanotechnology

Background:

• Effective wound management for acute and traumatic injuries requires rapid coverage and bioactive interventions.
• Current treatments often fall short in providing immediate protection and promoting tissue regeneration simultaneously.

Purpose of the Study:

• To develop an instant film-forming nanospray bandage (QSFNPs_FFS) for multifunctional wound care.
• To incorporate quercetin-loaded silk fibroin nanoparticles (QSFNPs) for sustained drug release and enhanced tissue regeneration.

Main Methods:

• Engineered a nanospray bandage with clinically relevant excipients for rapid film formation.
• Incorporated quercetin-loaded silk fibroin nanoparticles (QSFNPs) for sustained quercetin release.
• Evaluated the nanospray bandage in rabbit full-thickness wound models.

Main Results:

• The nanospray bandage formed a protective film with broad-spectrum antibacterial, occlusive, and UVB protection.
• The formulation attenuated oxidative stress and regulated early inflammatory responses.
• Quercetin release suppressed pro-fibrotic signaling (YAP and TGFβ1), leading to accelerated scar-free healing.

Conclusions:

• The developed nanospray bandage offers a promising multifunctional strategy for acute and traumatic wound management.
• It provides immediate wound protection and promotes scar-free tissue regeneration through bioactive quercetin delivery.
• The study highlights the translational potential of this advanced wound care technology.