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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
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A retrospective study on the reasons for second molar extraction.
Chengyi Wang1, BaoCheng Yao1, Shiyu Qiu1
1Dental Department, Peking University Third Hospital, Peking, China.
Frontiers in Dental Medicine
|November 26, 2025
Summary
Endodontic issues are the primary reason for second molar extractions, followed by periodontal disease. Advanced age increases risks for both, while impacted third molars are more common in mandibular extractions.
Area of Science:
- Dentistry
- Oral Surgery
- Dental Public Health
Background:
- Second molar extractions are common dental procedures.
- Reasons include endodontics, periodontal disease, and impacted third molars.
Purpose of the Study:
- To analyze the proportional distribution of causes for second molar extraction.
- To investigate age-related correlations with extraction causes.
Main Methods:
- Retrospective analysis of 1,818 patient records and imaging data (2020-2022).
- Data collected on demographics, diagnoses, and extraction causes.
- Inter-rater reliability assessed using Kappa testing.
Main Results:
- Endodontic factors (57.43%) and periodontal factors (32.40%) were the leading causes.
- Both endodontic and periodontal issues showed significant age-related correlations (p<0.05).
- Impacted third molars (10.01%) were more prevalent in mandibular (13.97%) than maxillary (5.73%) extractions.
Conclusions:
- Endodontic and periodontal factors are the predominant reasons for second molar extraction.
- Older age is linked to higher risks of extraction due to endodontic and periodontal disease.
- Impacted third molars disproportionately affect mandibular second molar extraction rates.

