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Related Concept Videos

Cleavage and Blastulation01:33

Cleavage and Blastulation

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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Neurulation01:30

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Gastrulation01:56

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Development of Blood Vessels01:07

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The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
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Embryonic Connective Tissues01:20

Embryonic Connective Tissues

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During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
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Zygotic Development And Stem Cell Formation01:10

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Related Experiment Video

Updated: Jan 10, 2026

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane
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In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane

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Primate amnion development.

Nikola Sekulovski1, Amber E Carleton1, Chien-Wei Lin2

  • 1Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Development (Cambridge, England)
|November 26, 2025
PubMed
Summary
This summary is machine-generated.

Human amnion formation is vital for pregnancy. New stem cell models and embryo analyses reveal key molecular events in primate amniogenesis, aiding understanding of early human development.

Keywords:
AmnionEarly human developmentHuman pluripotent stem cells

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Isolation, Cryopreservation and Culture of Human Amnion Epithelial Cells for Clinical Applications
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Related Experiment Videos

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In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane
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Isolation, Cryopreservation and Culture of Human Amnion Epithelial Cells for Clinical Applications
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Isolation, Cryopreservation and Culture of Human Amnion Epithelial Cells for Clinical Applications

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Reproductive Biology

Background:

  • The amnion is crucial for fetal development and pregnancy health.
  • Early human amniogenesis occurs during implantation and cannot be studied in utero.
  • Understanding amnion specification is key to reproductive health.

Purpose of the Study:

  • To highlight recent findings on primate amnion specification.
  • To emphasize current understandings of morphogenesis and key players in amniotic ectoderm specification.
  • To integrate insights from human stem cell models and embryo transcriptomic analyses.

Main Methods:

  • Utilizing human stem cell-derived model systems.
  • Performing single-cell and spatial transcriptomic analyses on early human and monkey embryos.
  • Reviewing recent findings on primate amniogenesis.

Main Results:

  • New insights into the molecular and cellular events of early amniogenesis in primates.
  • Identification of BMP-driven transcriptional signatures associated with amnion specification.
  • Characterization of key molecular players involved in primate amniotic ectoderm formation.

Conclusions:

  • Recent advancements in stem cell models and transcriptomic analyses have shed light on primate amnion development.
  • BMP signaling and specific molecular players are critical for amniotic ectoderm specification.
  • These findings advance our understanding of early human embryonic development and pregnancy.