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Updated: Jan 10, 2026

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

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Published on: December 27, 2024

Multifunctional Prussian-Blue-Based Nanocomposite Hydrogel for Infected Wound Regeneration.

Pengchao Zhao¹, Zhishen Zhang¹, Dianhao Gong¹

¹College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, China.

Gels (Basel, Switzerland)

|November 26, 2025

Summary

This summary is machine-generated.

This study introduces a novel injectable nanocomposite hydrogel (DPB-ODQ) that effectively combats bacterial infections and promotes wound healing. Its unique properties include rapid gelling, self-healing, and excellent photothermal antibacterial activity.

Keywords:

Prussian blue nanoparticle Schiff-base hydrogel antibacterial property photothermal ability wound healing

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Area of Science:

Biomaterials Science
Nanotechnology
Regenerative Medicine

Background:

Bacterial infections and inflammation significantly impede wound healing.
Developing advanced materials is crucial for overcoming these challenges in wound care.

Purpose of the Study:

To develop and characterize a novel injectable nanocomposite hydrogel (DPB-ODQ) for enhanced wound healing.
To evaluate the hydrogel's physical properties, antibacterial efficacy, and in vivo wound healing performance.

Main Methods:

Fabrication of DPB-ODQ hydrogel using polydopamine-modified Prussian blue nanoparticles and a quaternized chitosan-based Schiff-base network.
Assessment of hydrogel properties: swelling, gelling speed, mass retention, self-healing, adhesion, and photothermal performance.
Evaluation of antibacterial activity against Staphylococcus aureus and Escherichia coli, in vitro cell studies, and in vivo wound healing experiments in mice.

Main Results:

The DPB-ODQ hydrogel exhibited rapid gelling (45 s), high swelling (730%), excellent self-healing, and good adhesion (13.5 kPa).
The hydrogel demonstrated significant photothermal performance and achieved a bactericidal rate exceeding 96% against S. aureus and E. coli.
In vivo studies showed an impressive 92.82% wound healing rate in mice, with enhanced fibroblast proliferation and collagen deposition.

Conclusions:

The DPB-ODQ hydrogel is a promising injectable material for wound healing due to its multifaceted properties.
Its combined photothermal and antibacterial capabilities effectively address infection and promote tissue regeneration.
This advanced hydrogel holds potential for clinical applications in treating complex wounds.