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How to Administer Near-Infrared Spectroscopy in Critically ill Neonates, Infants, and Children
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Monitoring and Targeted Regulation of Oxygen Metabolism in Pediatric Sepsis: Current Paradigms and Future

Hong Zheng1, Lijun Guan1, Yiyao Bao1

  • 1Department of Surgical Intensive Care Unit, National Clinical Research Center for Children and Adolescents' Health and Diseases, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China.

International Journal of Molecular Sciences
|May 27, 2026
PubMed

Insights

Pediatric sepsis involves oxygen metabolism disorders, impacting oxygen delivery and cellular energy. Monitoring these parameters aids in early detection, treatment, and prognosis for better outcomes in critically ill children.

Area of Science:

  • Critical Care Medicine
  • Pediatric Infectious Diseases
  • Biochemistry

Background:

  • Pediatric sepsis is a life-threatening condition characterized by systemic inflammation and impaired oxygen metabolism.
  • The imbalance between oxygen delivery and demand, along with cellular energy dysfunction, significantly contributes to high mortality rates in children.

Purpose of the Study:

  • To systematically review the pathophysiology of oxygen metabolism disorders in pediatric sepsis.
  • To highlight the clinical significance of key monitoring indices for early identification, severity assessment, and treatment guidance.
  • To explore novel therapeutic strategies and future perspectives for optimizing oxygen metabolism in pediatric sepsis management.

Main Methods:

  • Systematic review of existing literature on pediatric sepsis and oxygen metabolism.
  • Analysis of current clinical applications of monitoring indices like blood lactate and central venous oxygen saturation.
  • Integration of recent research on therapeutic interventions and emerging biomarkers.

Main Results:

  • Oxygen metabolism parameters are crucial for assessing tissue perfusion and cellular oxygen use in pediatric sepsis.
  • Key indices such as blood lactate and central venous oxygen saturation are vital for clinical decision-making.
  • Emerging therapies and biomarkers show promise for improving patient outcomes.

Conclusions:

  • Optimizing oxygen metabolism is central to managing pediatric sepsis.
  • Continuous monitoring and targeted therapies are essential for improving survival rates.
  • Future research into novel biomarkers and metabolomics will further refine clinical management strategies.

Keywords:
lactatemicrocirculationoxygen metabolismpediatric sepsistherapeutic strategiestissue perfusion

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