Related Experiment Video
Updated: Jan 10, 2026
11:32
Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
7.4K
FGF12 Enhances Prostate Cancer Cell Survival via the YB1-lncRNA Axis.
Zechao Huang1, Sonia H Y Kung1, Hans Adomat1
1The Vancouver Prostate Centre, Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Cells
|November 26, 2025
Summary
Fibroblast growth factor 12 (FGF12) drives aggressive neuroendocrine prostate cancer by stabilizing oncogenic RNAs. Targeting the FGF12-YB1-lncRNA pathway offers new therapeutic strategies for this therapy-resistant cancer.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Treatment-induced neuroendocrine prostate cancer (t-NEPC) is an aggressive, therapy-resistant subtype of prostate cancer.
- Lineage plasticity and poor response to standard therapies characterize t-NEPC.
- Post-transcriptional regulation's role in t-NEPC is less understood than transcriptional mechanisms.
Purpose of the Study:
- To identify novel post-transcriptional regulators of t-NEPC.
- To elucidate the molecular mechanisms driving t-NEPC progression.
- To explore potential therapeutic targets for t-NEPC.
Main Methods:
- Transcriptomic analysis of patient biopsies, xenografts, and cell models.
- Immunohistochemistry validation in archival specimens.
- Functional assays, RNA sequencing, and affinity purification-mass spectrometry.
Main Results:
- Fibroblast growth factor 12 (FGF12) expression is significantly elevated in t-NEPC.
- FGF12 promotes cancer cell survival against chemotherapeutic agents.
- FGF12 interacts with Y-box binding protein 1 (YB1) to stabilize oncogenic long noncoding RNAs (NEAT1, MALAT1).
Conclusions:
- A novel FGF12-YB1-lncRNA signaling axis drives t-NEPC progression.
- This pathway represents a potential therapeutic target for aggressive prostate cancer.
- Understanding post-transcriptional regulation is crucial for t-NEPC treatment strategies.
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