Related Experiment Video

Updated: Feb 27, 2026

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
06:35

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

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Beyond Ion Channels: Emerging Roles of FGF12 in Cellular Regulation and Cancer Progression

Zechao Huang1, Xuesen Dong1,2

  • 1The Vancouver Prostate Centre, Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.

Cells
|February 26, 2026
PubMed

Insights

Fibroblast growth factor 12 (FGF12) impacts cancer progression beyond ion channels. This review explores FGF12

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Fibroblast growth factor 12 (FGF12) is known for modulating voltage-gated ion channels.
  • Emerging evidence suggests FGF12 has functions beyond ion channel regulation, especially in cancer.

Purpose of the Study:

  • To review the non-canonical functions of FGF12.
  • To highlight FGF12's emerging roles in cellular regulation and oncogenic progression.
  • To discuss potential therapeutic targeting of FGF12 in malignancies.

Main Methods:

  • Literature review of recent studies on FGF12.
  • Analysis of FGF12's role in tumor survival, therapeutic resistance, and prognosis.
  • Exploration of signaling pathways independent of ion channel interactions.

Main Results:

  • FGF12 upregulation is linked to tumor survival and poor prognosis.
  • FGF12 contributes to therapeutic resistance.
  • Non-canonical FGF12 functions involve novel signaling pathways in cancer.

Conclusions:

  • FGF12 plays significant roles in cancer progression independent of its ion channel functions.
  • Understanding FGF12's non-canonical functions offers new therapeutic strategies for cancer.
  • FGF12 represents a potential novel target for anti-cancer therapies.
Keywords:
cancer progressioncellular regulationfibroblast growth factor 12 (FGF12)

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