Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

417
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
417
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

13.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.7K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota and Type 2 Diabetes.

International journal of molecular sciences·2026
Same author

Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective.

International journal of molecular sciences·2025
Same author

Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management.

Nutrients·2024
Same author

The Other Side of the Perfect Cup: Coffee-Derived Non-Polyphenols and Their Roles in Mitigating Factors Affecting the Pathogenesis of Type 2 Diabetes.

International journal of molecular sciences·2024
Same author

The Perfect Cup? Coffee-Derived Polyphenols and Their Roles in Mitigating Factors Affecting Type 2 Diabetes Pathogenesis.

Molecules (Basel, Switzerland)·2024
Same author

The Flavonoid Kaempferol Ameliorates Streptozotocin-Induced Diabetes by Suppressing Hepatic Glucose Production.

Molecules (Basel, Switzerland)·2018

Related Experiment Video

Updated: Jan 10, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K

Type 3 Diabetes: Linking Insulin Resistance to Cognitive Decline.

Brooke Chapple1, Emily Bayliss1, Seth Woodfin2

  • 1Department of Biology and Chemistry, School of Health Sciences, Liberty University, Lynchburg, VA 24515, USA.

Diseases (Basel, Switzerland)
|November 26, 2025
PubMed
Summary

Type 3 diabetes involves brain insulin resistance, potentially causing cognitive decline and Alzheimer's disease. Exploring the gut-brain axis may reveal new prevention and treatment strategies for neurodegeneration.

Keywords:
Alzheimer’s diseasecognitive declinegut–brain axisinsulin resistancemetabolic healthneurodegenerationneuroinflammationoxidative stresssynaptic dysfunctiontype 3 diabetes

More Related Videos

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

10.2K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.8K

Related Experiment Videos

Last Updated: Jan 10, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K
Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

10.2K
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
08:32

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain

Published on: January 4, 2018

10.8K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Metabolic Disorders

Background:

  • Type 3 diabetes (T3D) is defined by brain insulin resistance and deficiency, leading to neuronal damage, inflammation, and cognitive impairment.
  • These processes are linked to neurodegenerative conditions like Alzheimer's disease, but T3D mechanisms are not fully understood.
  • The gut-brain axis, influenced by diet, is a potential area for investigating T3D and cognitive health.

Purpose of the Study:

  • To review the links between insulin resistance and cognitive decline.
  • To explore the gut-brain axis's role in Type 3 diabetes.
  • To propose interventions for slowing aging and reducing cognitive decline risk.

Main Methods:

  • Literature review focusing on insulin resistance, cognitive decline, and the gut-brain axis.
  • Analysis of existing research on Type 3 diabetes mechanisms.
  • Synthesis of findings to propose potential therapeutic avenues.

Main Results:

  • Insulin resistance in the brain is associated with neuronal dysfunction and cognitive impairment.
  • The gut-brain axis presents a promising pathway for understanding and potentially managing T3D.
  • Dietary interventions may play a role in mitigating T3D and associated cognitive issues.

Conclusions:

  • Further research into the gut-brain axis is crucial for understanding Type 3 diabetes.
  • Targeting insulin resistance and inflammation may help prevent cognitive decline.
  • The classification and primary drivers of T3D require further investigation, with potential links to neurodegeneration.