Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IDR searcher: a search engine solution for public image resources.

Bioinformatics (Oxford, England)·2026
Same author

Search, organize, aggregate and share image data with BioFile Finder (BFF).

Nature methods·2026
Same author

Hybrid learning: a combination of self-supervised and supervised learning for joint MRI reconstruction and denoising in low-field MRI.

Physics in medicine and biology·2026
Same author

Excited-State Electron-Phonon Coupling in Pristine and Doped Iron Pyrite.

The journal of physical chemistry letters·2026
Same author

Self-Supervised Joint Reconstruction and Denoising of T2-Weighted PROPELLER MRI of the Lung at 0.55T.

Magnetic resonance in medicine·2025
Same author

Type 3 Diabetes: Linking Insulin Resistance to Cognitive Decline.

Diseases (Basel, Switzerland)·2025

Related Experiment Videos

The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota and Type 2 Diabetes.

Emily Bayliss1, Landri Shope1, Seth Woodfin2

  • 1School of Health Sciences, Department of Biology and Chemistry, Liberty University, Lynchburg, VA 24515, USA.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary

Dietary polyphenols may help manage type 2 diabetes (T2D) by improving gut health. However, T2D can affect how the body uses these compounds, impacting their effectiveness.

Keywords:
bioavailability and metabolismgut microbiomehost-microbiome interactionsinflammationinsulin resistanceoxidative stresspolyphenolsprecision nutritionshort-chain fatty acids (SCFAs)type 2 diabetes mellitus (T2D)

Related Experiment Videos

Area of Science:

  • Metabolic disease research
  • Gut microbiome studies
  • Nutritional science

Background:

  • Type 2 diabetes (T2D) is a global health issue marked by insulin resistance and pancreatic beta-cell dysfunction.
  • Gut dysbiosis, an imbalance in gut microbes, is increasingly recognized as a key factor in T2D development.
  • Dietary polyphenols, found in plant foods, offer antioxidant and anti-inflammatory benefits, potentially improving metabolic health.

Purpose of the Study:

  • To review the intricate connections between T2D, dietary polyphenols, and the gut microbiota.
  • To explore how these three factors dynamically interact.
  • To propose new strategies for T2D prevention and management based on these interactions.

Main Methods:

  • Literature review of studies on T2D, gut microbiota, and dietary polyphenols.
  • Analysis of the bidirectional relationship between the diabetic state and polyphenol bioavailability.
  • Synthesis of evidence to propose a triangular interaction model.

Main Results:

  • Gut dysbiosis is a significant factor in T2D pathophysiology.
  • Polyphenols can modulate gut microbiota, potentially ameliorating dysbiosis.
  • The diabetic condition may alter polyphenol metabolism, absorption, and bioavailability, affecting therapeutic outcomes.

Conclusions:

  • A complex, dynamic interplay exists between T2D, gut microbiota, and dietary polyphenols.
  • Understanding this triangular relationship is crucial for developing effective T2D prevention and management strategies.
  • Further research into polyphenol bioavailability in diabetic states is warranted.