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A Rare Case of Alternaria citri Keratitis Successfully Treated with Voriconazole
Maura Bertazzolo1, Giorgia Boaretto1, Elena Zani2
1Department of Microbiology, Bianalisi S.p.A., 20841 Carate Brianza, MB, Italy.
Abstract:
The genus Alternaria comprises several species of dematiaceous hyphomycetes known to cause opportunistic infections in humans. Over the past two decades, fungal infections have emerged as a significant cause of morbidity and mortality, particularly among immunocompromised individuals. Such infections often occur following disruption of the skin or corneal epithelial barrier, especially in patients with pre-existing ocular conditions or compromised immune status. This case report describes a rare instance of fungal keratitis (FK) caused by Alternaria citri in a 71-year-old male who presented with an acute onset of eye infection. The patient showed a favorable response to treatment with voriconazole.
Insights
This case report details a rare fungal keratitis caused by Alternaria citri in an immunocompromised patient. Early diagnosis and treatment with voriconazole led to a favorable outcome, highlighting effective management strategies for this opportunistic infection.
Area of Science:
- Medical Mycology
- Ophthalmology
- Infectious Diseases
Background:
- Opportunistic fungal infections are increasing, especially in immunocompromised individuals.
- Dematiaceous hyphomycetes, such as Alternaria species, can cause severe infections.
- Fungal keratitis often occurs after disruption of the corneal barrier, particularly in vulnerable patients.
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