Related Experiment Video
Updated: Jan 6, 2026
11:09
Chromatin Isolation by RNA Purification ChIRP
Published on: March 25, 2012
88.0K
Non-Coding RNAs and Their Role in Maintaining Epidermal Homeostasis
Daniil D Romashin1, Tatiana V Tolstova1, Alexander L Rusanov1
1Institute of Biomedical Chemistry, Moscow 119121, Russia.
Current Issues in Molecular Biology
|November 26, 2025
Summary
Non-coding RNAs (ncRNAs) are vital for skin health, regulating epidermal homeostasis, differentiation, and wound healing. ncRNA-based therapies show promise for treating skin conditions like psoriasis and chronic wounds.
Area of Science:
- Dermatology and Molecular Biology
- Focuses on the skin's biological mechanisms and the role of genetic regulators.
Background:
- Non-coding RNAs (ncRNAs) are increasingly recognized for their critical biological roles.
- Evidence highlights ncRNAs' importance in maintaining epidermal homeostasis.
- ncRNAs are implicated in skin differentiation, wound healing, and diseases like psoriasis.
Purpose of the Study:
- To review the diverse roles of ncRNAs in epidermal homeostasis.
- To explore ncRNA mechanisms in normal and pathological skin conditions.
- To discuss the therapeutic potential of ncRNAs in dermatology.
Main Methods:
- Literature review of ncRNA research in epidermal biology.
- Analysis of ncRNA involvement in skin differentiation and wound repair.
- Examination of ncRNA dysregulation in skin diseases.
Main Results:
- ncRNAs are key regulators of epidermal differentiation and wound healing.
- Dysfunctional ncRNAs are associated with pathological skin conditions.
- ncRNA-based strategies are emerging for therapeutic and diagnostic applications.
Conclusions:
- ncRNAs are essential for maintaining skin health and function.
- Targeting ncRNAs offers novel therapeutic avenues for dermatological disorders.
- Further research into ncRNA mechanisms will advance skin disease treatment.
Related Concept Videos
01:12Renewal of Skin Epidermal Stem Cells
2.9K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.9K
02:39lncRNA - Long Non-coding RNAs
9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
02:39lncRNA - Long Non-coding RNAs
3.4K
3.4K
01:53RNA Stability
35.6K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.6K
01:14Maintenance of the ES Cell State
2.6K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.6K
01:20Types of RNA
8.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
8.8K