Cefazolin-induced coagulopathy: a case report

Area of Science:

• Pharmacology
• Hematology
• Critical Care Medicine

Background:

• Cefazolin is a commonly used antibiotic, but rare adverse effects can occur.
• Coagulopathy is a potential complication associated with certain medications.
• Prompt identification of drug-induced adverse events is critical in patient management.

Purpose of the Study:

• To report a case of cefazolin-induced coagulopathy.
• To emphasize the importance of suspecting this rare adverse effect.
• To highlight the clinical presentation and management of cefazolin-induced coagulopathy.

Main Methods:

• A case report of a 78-year-old woman receiving high-dose cefazolin therapy.
• Monitoring of international normalized ratio (INR) levels during treatment.
• Diagnostic workup to rule out other causes of coagulopathy.
• Discontinuation of cefazolin and administration of vitamin K.

Main Results:

• The patient developed significantly elevated INR levels (15-20) on day 4 of cefazolin treatment.
• Cefazolin-induced coagulopathy was suspected after excluding other causes.
• Discontinuation of cefazolin and vitamin K supplementation led to rapid INR normalization.

Conclusions:

• Cefazolin-induced coagulopathy is a rare, potentially life-threatening complication.
• It can present with or without overt bleeding.
• Heightened awareness and familiarity with risk factors are essential for timely recognition and management.