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Related Experiment Video

Updated: Jan 10, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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Plasmonic Interfaces for Advanced Profiling of Cell-Free Circulating Biomarkers.

Chao Wang1,2, Yuhao Wu1,2,3, Panida Cen1,2,4

  • 1Institute for Health Innovation & Technology, National University of Singapore, Singapore 117599, Singapore.

ACS Applied Materials & Interfaces
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Cell-free biomarkers like extracellular vesicles (EVs) offer real-time disease insights. Surface plasmon resonance (SPR) with engineered interfaces enhances their detection for personalized medicine.

Keywords:
cell-free circulating biomarkerscolloidal nanomaterialsinterfacesplanar nanostructuresplasmonic biosensing

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Area of Science:

  • Biomarker Discovery
  • Nanotechnology
  • Personalized Medicine

Background:

  • Cell-free biomarkers, including extracellular vesicles (EVs), are abundant in bodily fluids and offer potential for minimally invasive disease monitoring.
  • Their diverse biophysical and biomolecular characteristics provide rich information for personalized medicine.
  • Current analytical technologies struggle to accommodate the wide spectrum of cell-free biomarker sizes and compositions.

Purpose of the Study:

  • To review the characteristics of cell-free circulating biomarkers.
  • To overview plasmonic sensing mechanisms for biomarker detection.
  • To highlight advanced plasmonic interface designs for enhanced cell-free biomarker analysis.

Main Methods:

  • Discussion of cell-free biomarker properties.
  • Overview of surface plasmon resonance (SPR) sensing principles.
  • Analysis of plasmonic interfaces utilizing colloidal nanoparticles and arrayed nanostructures.

Main Results:

  • Engineered plasmonic interfaces are crucial for accommodating diverse biomarker characteristics.
  • SPR technology, particularly with tailored interfaces, shows promise for overcoming current detection limitations.
  • Various plasmonic interface designs (nanoparticles, nanostructures) enable enhanced detection.

Conclusions:

  • Surface plasmon resonance (SPR) with engineered plasmonic interfaces is a powerful tool for detecting diverse cell-free biomarkers.
  • Technological advancements in plasmonic interfaces are key to facilitating biomarker discovery and clinical translation.
  • This approach holds significant promise for next-generation personalized medicine.