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StomachDB: An Integrated Multi-Omics Database for Gastric Diseases.
Gang Wang1,2,3, Zhe Sun2, Shiou Yih Lee4
1Research Center of Oncology, Guangxi Academy of Medical Sciences, Nanning 530021, China.
Biology
|November 27, 2025
Summary
StomachDB is a new multi-omics database for gastric diseases, integrating diverse data types to advance understanding of molecular progression and identify therapeutic targets for conditions like gastric cancer.
Area of Science:
- Gastroenterology and Molecular Biology
- Bioinformatics and Computational Biology
Background:
- Gastric diseases pose a significant global health burden.
- Understanding molecular progression in precancerous lesions is crucial for improved diagnosis and treatment.
- Existing research often limited by single-omics approaches.
Purpose of the Study:
- To introduce StomachDB, the first comprehensive multi-omics database for gastric diseases.
- To provide an integrated platform for exploring complex molecular mechanisms.
- To facilitate the discovery of diagnostic markers and therapeutic targets.
Main Methods:
- Integrated 6 types of biological data: genomics, transcriptomics (including single-cell and spatial), proteomics, metabolomics, and therapeutic information.
- Compiled data for 44 gastric-related pathologies in humans and mice.
- Developed a user-friendly analytics platform for data querying, visualization, and download.
Main Results:
- StomachDB contains ~2.5 million curated profiles and 268,394 disease-gene associations.
- The database enables investigation of gene significance (e.g., CDH1) across omics levels.
- Identified potential therapeutic targets through cataloging drug, herbal medicine, and probiotic interactions.
Conclusions:
- StomachDB offers a powerful, open-access resource for studying gastric disease molecular mechanisms.
- The integrative multi-omics approach overcomes limitations of single-omics analyses.
- Facilitates systematic exploration of biological interactions and regulatory pathways for enhanced gastric disease research.
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