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Related Experiment Video

Updated: Jan 10, 2026

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
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Multimodality Assessment for Durable Mechanical Circulatory Support Implantation.

Luca Martini1, Antonio Pagliaro2, Francesca Maria Righini2

  • 1Department of Medical Biotechnologies, Division of Cardiology, University of Siena, 53100 Siena, Italy.

Diagnostics (Basel, Switzerland)
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Advanced heart failure (AdHF) management with durable mechanical circulatory support (DMCS) like LVADs requires thorough preoperative evaluation. Multimodal assessments optimize patient selection and improve outcomes for these complex heart failure cases.

Keywords:
DMCSLVADadvanced heart failurecardiac magnetic resonanceright heart catheterizationspeckle-tracking echocardiography

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Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Global prevalence of advanced heart failure (AdHF) is rising due to aging populations and better chronic heart failure (CHF) survival.
  • Durable Mechanical Circulatory Support (DMCS), especially Left Ventricular Assist Devices (LVADs), is crucial for AdHF treatment.
  • Successful DMCS implantation hinges on comprehensive preoperative evaluation.

Purpose of the Study:

  • To outline the essential components of preoperative evaluation for DMCS implantation.
  • To highlight the role of various diagnostic modalities in risk stratification.
  • To emphasize the importance of a multidisciplinary approach in optimizing patient selection.

Main Methods:

  • Cardiac imaging (echocardiography, CMR) for structural and functional assessment.
  • Right heart catheterization (RHC) for hemodynamic evaluation.
  • Cardiopulmonary exercise testing (CPET) for functional capacity assessment.
  • Systemic comorbidity screening (renal, hepatic, oncologic, psychiatric).

Main Results:

  • Echocardiography/CMR findings (e.g., low ejection fraction, specific RV strain) predict outcomes.
  • RHC identifies hemodynamic contraindications (e.g., high PVR, low PAPi).
  • CPET reveals limited functional reserve (e.g., low peak VO2).
  • Systemic comorbidities significantly impact surgical risk.

Conclusions:

  • A multimodal preoperative assessment integrating cardiac, hemodynamic, and systemic data is vital for DMCS candidacy.
  • Multidisciplinary team collaboration is key to optimizing selection and outcomes for DMCS.
  • This comprehensive approach improves the management of patients with advanced heart failure.