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Published on: October 18, 2021
Clinical Application of Cell-Based Approaches in Maxillary Sinus Floor Augmentation: A Systematic Review and
Sung-Hoon Han1, Saet-Byeol Han2, Greg Shinho Park3
1Department of Orthodontics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Incorporating stem cells into maxillary sinus floor augmentation shows a positive trend for bone regeneration, especially mesenchymal stem cells. Further research is needed to confirm these potential clinical advantages for dental implants.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Medicine
- Biomaterials Science
Background:
- Maxillary sinus floor augmentation is crucial for dental implant success.
- Stem cells are investigated for their potential to enhance bone regeneration in these procedures.
- Existing literature lacks a comprehensive synthesis of stem cell efficacy in this context.
Purpose of the Study:
- To systematically review and meta-analyze the effects of incorporating stem cells in maxillary sinus floor augmentation.
- To compare the outcomes of stem cell-enhanced augmentation with traditional methods.
- To identify potential benefits and areas for future research.
Main Methods:
- Systematic review and meta-analysis of published studies.
- Searches conducted in Medline (PubMed), Embase, and Cochrane Library up to July 2025.
- Inclusion criteria applied to five selected studies for meta-analysis.
Main Results:
- Pooled analysis showed a standardized mean difference of 1.06 for new bone formation (95% CI: -0.31 to 2.44).
- Subgroup analysis of mesenchymal stem cells versus autogenous bone yielded a standardized mean difference of 0.88 (95% CI: 0.34 to 1.42).
- A positive trend favoring stem cells was observed, though not statistically significant at the pooled level; xenograft combinations showed promise.
Conclusions:
- Mesenchymal stem cells show a promising trend for improving bone regeneration in maxillary sinus augmentation.
- Combining stem cells with xenografts may offer advantages over autogenous bone with xenografts.
- Standardized research is essential to validate long-term outcomes and clinical efficacy.
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