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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

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Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
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Neuroplasticity01:01

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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
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Modeling in Therapy01:26

Modeling in Therapy

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Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
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Schizophrenia01:17

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Updated: Jan 10, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

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Neuroplasticity Across the Autism-Schizophrenia Continuum.

Evangelia Kesidou1,2, Nikolaos Mitsoudis2, Olympia Damianidou2

  • 1Laboratory of Physiology, Faculty of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Biomedicines
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Brain plasticity differs in Autism Spectrum Disorder and Schizophrenia, impacting cognitive function. Interventions targeting plasticity show promise but require larger trials for efficacy in these neurodevelopmental disorders.

Keywords:
Autism spectrum disorderSchizophrenianeurodegenerationneuroplasticityneurorehabilitation

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Area of Science:

  • Neuroscience
  • Neurobiology
  • Developmental Psychology

Background:

  • Brain plasticity is crucial for nervous system adaptation.
  • It involves synaptic changes influencing cognition and behavior.
  • Disorders like Autism Spectrum Disorder (ASD) and Schizophrenia exhibit distinct plasticity alterations.

Purpose of the Study:

  • To contrast plasticity mechanisms and developmental timing in ASD and Schizophrenia.
  • To evaluate interventions targeting plasticity for cognitive and behavioral improvement.
  • To offer an integrated perspective on plasticity-based therapies for neuropsychiatric disorders.

Main Methods:

  • Literature review and critical analysis of existing studies.
  • Comparison of preclinical and clinical evidence for plasticity interventions.
  • Evaluation of molecular mechanisms and therapeutic strategies.

Main Results:

  • ASD shows early hyperplasticity and excitation-inhibition imbalance.
  • Schizophrenia is characterized by adolescent overpruning and NMDAR hypofunction.
  • Interventions show symptom-domain-specific effects, necessitating further research.

Conclusions:

  • Targeting plasticity pathways offers potential for cognitive and behavioral gains in ASD and Schizophrenia.
  • Cognitive remediation in Schizophrenia improved executive function and hippocampal volume.
  • Virtual reality training in ASD enhanced attention and planning skills, indicating protocol-dependent efficacy.