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Related Experiment Video

Updated: Jan 10, 2026

Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse

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Published on: March 8, 2013

Non-Contrast Radiation-Free NIR Lung Imaging.

Jiří Votruba¹, Martin Drahanský², Tomáš Goldmann³

¹I. Clinic of Tuberculosis and Respiratory Diseases, General University Hospital in Prague, 128 08 Prague, Czech Republic.

|November 27, 2025

Summary

This summary is machine-generated.

This study introduces a new, radiation-free optical technique using near-infrared (NIR) translumination for locating solitary pulmonary nodules (SPNs). This method visualizes lung tissue, potentially improving biopsy guidance without X-rays.

Keywords:

bronchoscopy image processing near-infrared imaging pleuroscopy solitary pulmonary nodule translumination

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Area of Science:

Pulmonary Medicine
Medical Imaging
Optical Physics

Background:

Solitary pulmonary nodule (SPN) localization is difficult, often requiring ionizing radiation.
Current endoscopic navigation methods for SPN detection face limitations.
There is a need for non-ionizing imaging techniques for pulmonary procedures.

Purpose of the Study:

To develop and assess a novel, radiation-free optical method for SPN localization.
To utilize near-infrared (NIR) translumination for visualizing lung parenchyma.
To evaluate the feasibility of NIR translumination for intra-thoracic visualization.

Main Methods:

A miniaturized NIR light source was inserted into the bronchial tree.
Transmitted and scattered NIR light was detected from the pleural side using minipleuroscopy and a CMOS camera.
The technique leverages intrinsic optical properties of lung tissue, avoiding contrast agents.

Main Results:

Clear visualization of tissue structures through up to 4 cm of ex vivo porcine lung parenchyma.
Consistent detection of bronchial NIR illumination from the pleural cavity in a ventilated pig.
Distinct imaging of lobular structures and bronchial mucosa was achieved.

Conclusions:

Near-infrared (NIR) translumination offers radiation-free intra-thoracic visualization.
This technique shows promise as an adjunct for biopsy guidance in pulmonary procedures.
Further research is needed for clinical validation and translation to human applications.