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MicroRNAs01:22

MicroRNAs

3.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
MicroRNAs01:22

MicroRNAs

23.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.5K
3.5K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

13.1K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.1K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.5K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.5K

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Updated: Jan 10, 2026

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
10:40

CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis

Published on: April 25, 2022

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Long noncoding RNAs and microRNAs in Endometriosis.

Edi Muhaxhiri1,2, Maruša Debeljak1,3, Katarina Trebušak Podkrajšek1,3

  • 1Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

Biomedicines
|November 27, 2025
PubMed
Summary

Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are key regulators in endometriosis development. These non-coding RNAs show potential as diagnostic biomarkers and therapeutic targets for this common gynecological disorder.

Keywords:
biomarkersendometriosislncRNAlong noncoding RNAsmiRNAmicroRNA

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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

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Area of Science:

  • Gynecology
  • Molecular Biology
  • Genetics

Background:

  • Endometriosis affects 10% of women and is linked to infertility.
  • Disease pathogenesis involves complex processes like inflammation, cell growth, and immune dysregulation.
  • The exact cause of endometriosis is still unknown.

Purpose of the Study:

  • To review and differentiate long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) with pathogenic roles versus altered expression in endometriosis.
  • To highlight the regulatory functions of specific lncRNAs and miRNAs in endometriosis.
  • To explore the potential of non-coding RNAs as diagnostic biomarkers and therapeutic targets.

Main Methods:

  • Literature review integrating transcriptomic and molecular studies.
  • Analysis of studies focusing on non-coding RNA involvement in endometriosis.
  • Identification of specific lncRNAs and miRNAs implicated in disease pathogenesis.

Main Results:

  • Specific lncRNAs (H19, MALAT1, LINC01116) are linked to chromatin remodeling, competing for endogenous RNAs, and signaling pathways.
  • Specific miRNAs (miR-200 family, miR-145, let-7b) regulate epithelial-mesenchymal transition, angiogenesis, and cell adhesion.
  • Non-coding RNAs are implicated in key endometriosis processes, distinguishing pathogenic roles from expression changes.

Conclusions:

  • Non-coding RNAs, including lncRNAs and miRNAs, play significant roles in endometriosis.
  • These molecules hold promise as diagnostic biomarkers and novel therapeutic targets for endometriosis.
  • Further research is needed to confirm findings and clarify the specific pathogenic mechanisms of non-coding RNAs in endometriosis.