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Sex Differences in Individuals at High Risk of Atrial Fibrillation: A Primary Care Community Cohort Study, 2015-2024
Jose Luis Clúa-Espuny1,2, Anna Panisello-Tafalla1, Alba Hernández-Pinilla3
1Equip d'Atenció Primària Tortosa Est, Gerència d'Atenció Primària i a la Comunitat de les Terres de l'Ebre, Institut Català de la Salut, 43500 Tortosa, Spain.
Biomedicines
|November 27, 2025
Summary
Men and women show different patterns of comorbidities and atrial fibrillation (AF) incidence. Tailored strategies are needed for early AF detection and risk management in primary care.
Area of Science:
- Cardiology
- Epidemiology
- Geriatrics
Background:
- Sex differences in atrial fibrillation (AF) epidemiology and outcomes are known.
- The role of sex in early AF detection and risk stratification in primary care is unclear.
Purpose of the Study:
- To investigate sex-specific differences in AF incidence and comorbidity patterns.
- To inform sex-tailored strategies for early AF detection and risk management.
Main Methods:
- Observational, retrospective cohort study of 9677 high-risk individuals (aged 65-95) without prior AF or stroke.
- Assessed incident AF and comorbidity prevalence over a defined follow-up period.
- Compared sex-specific differences in AF incidence and comorbidity clustering.
Main Results:
- Higher AF incidence observed in men (9.9%) compared to women (7.0%).
- Women had higher CHA2DS2-VA scores and cognitive impairment prevalence.
- Men showed clustering of cardiometabolic conditions; women exhibited higher cognitive decline.
Conclusions:
- Distinct sex-specific patterns in comorbidity clustering and AF incidence exist.
- Findings underscore the need for sex-tailored approaches in primary care for AF.
- Integrated risk management strategies should consider these sex differences.
Keywords:
agingatrial fibrillationchronic kidney diseasecognitive impairmentcomorbiditydementiaepidemiologyheart failureischemic diseaseprimary carerisk stratificationsexstrokeMore Related Videos
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