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Intraoperative Platelet-Rich Plasma (PRP) for Post-Cesarean Scar Healing: A Single-Center Randomized Controlled Pilot
Ana-Maria Brezeanu1,2, Dragoș Brezeanu1,2, Vlad-Iustin Tica1,2
16th Department, Faculty of Medicine, Ovidius University of Constanta, 900527 Constanta, Romania.
Healthcare (Basel, Switzerland)
|November 27, 2025
Summary
Platelet-rich plasma (PRP) treatment during Cesarean section (CS) showed promising trends for improved scar healing and reduced patient discomfort. Further research is needed to confirm these benefits for postpartum recovery.
Area of Science:
- Obstetrics and Gynecology
- Wound Healing Research
- Regenerative Medicine
Background:
- Cesarean section (CS) commonly leads to abdominal scarring, impacting patient recovery and quality of life.
- Platelet-rich plasma (PRP), a concentrate rich in growth factors, is being investigated for its potential to enhance wound healing.
- This study explores the efficacy of intraoperative PRP in improving outcomes for CS scars.
Purpose of the Study:
- To assess the impact of intraoperative platelet-rich plasma (PRP) on Cesarean section (CS) scar quality and patient-reported outcomes.
- To evaluate scar healing using multiple standardized assessment scales at early and later postpartum stages.
- To determine the safety and preliminary efficacy of PRP in CS wound management.
Main Methods:
- A single-center, single-blind randomized controlled trial involving 100 women undergoing elective CS.
- Participants were randomized to receive intraoperative PRP infiltration at incision sites or standard care.
- Scar assessment utilized the Patient and Observer Scar Assessment Scale (POSAS), Vancouver Scar Scale, and others at 7 and 40 days postpartum.
Main Results:
- PRP treatment demonstrated favorable trends in scar appearance and patient-reported discomfort at 7 days postpartum.
- Significant improvement in Patient and Observer Scar Assessment Scale (POSAS) patient scores was observed in the PRP group at 40 days (p=0.029).
- No adverse events were reported, indicating a favorable safety profile for intraoperative PRP.
Conclusions:
- Intraoperative platelet-rich plasma (PRP) shows potential for enhancing Cesarean section (CS) scar quality and reducing patient discomfort.
- Statistical significance was achieved for patient-reported scar assessment at 40 days postpartum.
- Larger, multicenter trials are recommended to validate these findings and establish PRP as a standard treatment for CS scars.
