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Ginger Powder-Based Pickering Emulsions: An Innovative Platform for Anticancer Drug Delivery.

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Summary
This summary is machine-generated.

Ginger powder stabilizes novel Pickering emulsions for effective doxorubicin delivery. These biodegradable formulations show good drug entrapment, sustained release, and anti-tumor efficacy, suggesting potential for targeted cancer therapy.

Keywords:
Pickering emulsioncontrolled antineoplastic drug releasedoxorubicin loading and releasegingernatural emulsifier and stabilizertargeted drug delivery systems

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Biodegradable Pickering emulsions offer versatile therapeutic applications.
  • Novel stabilizers are needed for advanced drug delivery systems.

Purpose of the Study:

  • To formulate and characterize a ginger powder-stabilized Pickering emulsion for doxorubicin delivery.
  • To evaluate the physicochemical properties, drug loading, release kinetics, and in vitro efficacy of the developed system.

Main Methods:

  • Physicochemical characterization using DLS, POM, Cryo-SEM, TEM, and rheology.
  • In vitro drug release studies at different pH values.
  • In vitro cytotoxicity assays on fibroblasts and breast cancer cells.

Main Results:

  • Ginger powder-stabilized Pickering emulsions (GA4_Pe) exhibited excellent stability (>1 month) and gel-like properties.
  • Doxorubicin-loaded emulsions (GA4_Pe@DOX) demonstrated efficient drug internalization and stability (>28 days).
  • Sustained, pH-dependent doxorubicin release was observed, with higher release at acidic pH.
  • GA4_Pe@DOX showed comparable cytotoxic effects to free doxorubicin on MCF7 cells with no toxicity to fibroblasts.

Conclusions:

  • Ginger powder is a viable stabilizer for creating stable, biodegradable Pickering emulsions for drug delivery.
  • The developed Pickering emulsion platform facilitates efficient doxorubicin entrapment and sustained release.
  • This ginger-based system shows promise as a selective therapeutic platform for topical delivery of antineoplastic drugs.