TiO₂ Nanotube-Enabled Glucose Biosensing: Transformative Insights from 2009 to 2024

Area of Science:

• Materials Science
• Nanotechnology
• Biomedical Engineering

Background:

• The global increase in diabetes necessitates improved glucose monitoring technologies.
• Traditional sensors face limitations in sensitivity, stability, and suitability for wearable devices.
• Titanium dioxide nanotube arrays (TiO2 NTAs) present a promising alternative due to their nanostructure and semiconductor properties.

Purpose of the Study:

• To review the application of TiO2 NTAs in glucose sensing.
• To explore various sensing modes including enzymatic, non-enzymatic, and photoelectrochemical (PEC) methods.
• To identify challenges and future directions for TiO2-based glucose monitoring.

Main Methods:

• Review of existing literature on TiO2 NTAs for glucose sensing.
• Analysis of different sensing strategies and their performance metrics.
• Exploration of material modifications and system design improvements.

Main Results:

• TiO2 NTAs demonstrate enhanced performance in various glucose sensing configurations.
• Enzymatic, non-enzymatic, and PEC sensors utilizing TiO2 NTAs show significant potential.
• Ongoing research focuses on overcoming limitations through novel materials and integrated designs.

Conclusions:

• TiO2 NTAs are a versatile platform for advanced glucose monitoring.
• Further research into material integration and system design is crucial for enhanced reliability.
• Future developments may lead to more adaptive and user-friendly diabetes management solutions.