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Related Concept Videos

Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...

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Stretchable Porous Membranes for Barrier Tissue Models with Real-Time Measurement and Biomimetic Cyclic Strain.

Alexander P M Guttenplan1, Joseph W F Robertson1, Darwin R Reyes1

  • 1National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

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Researchers developed stretchable electronic devices with integrated electrodes on porous membranes for biomedical applications. These devices enable real-time electrical impedance measurements and mechanical manipulation of model tissues.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Soft Robotics

Background:

  • Stretchable electronics mimic human tissues, advancing biomedical engineering and wearables.
  • Existing models use elastomeric membranes for mechanical simulation but lack integrated electrodes.
  • Measuring barrier tissue integrity and drug passage is crucial for various applications.

Purpose of the Study:

  • To develop microelectrodes directly on porous elastomeric membranes for enhanced sensing capabilities.
  • To integrate these membranes into vacuum-actuated devices for mechanical strain.
  • To demonstrate the suitability for electrical impedance measurements after mechanical stress.

Main Methods:

  • Lithographical patterning of gold electrodes onto porous polydimethylsiloxane (PDMS) membranes.
  • Incorporation of functionalized membranes into vacuum-actuated systems for cyclic stretching.
  • Electrical impedance measurements conducted under simulated cell culture conditions.

Main Results:

  • Successful fabrication of lithographically patterned gold electrodes on porous PDMS membranes.
  • Demonstrated electrical impedance sensing capabilities after 1000 stretching cycles.
  • The devices maintained functionality in fluids mimicking cell culture media.

Conclusions:

  • This technology enables electronic sensing and mechanical manipulation on stretchable porous membranes.
  • The developed system is suitable for real-time monitoring of model barrier tissues.
  • Future applications include cell trapping, tissue assembly, and advancements in wearables and robotics.