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Updated: Jan 10, 2026

Clinical Protocol of Producing Adipose Tissue-Derived Stromal Vascular Fraction for Potential Cartilage Regeneration
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Bridging the Gap: Do Patient-Reported Outcome Measures Reflect Objective Knee Function After Cartilage Repair?

Tizian Heinz1, Niklas Wegerich1, Sebastian Frischholz1

  • 1Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany.

Journal of Clinical Medicine
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Patient-reported outcomes after knee cartilage repair correlate with objective measures, but do not fully capture functional recovery. Combining subjective scores with clinical assessments is crucial for a comprehensive understanding of knee function.

Keywords:
German Cartilage Registry (KnorpelRegister DGOU)IKDCPROMcartilage repaircorrelationobjective knee score

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Area of Science:

  • Orthopedics
  • Sports Medicine
  • Regenerative Medicine

Background:

  • Focal knee cartilage defects cause significant pain and functional impairment.
  • Patient-reported outcome measures (PROMs) and objective scores assess knee status, but their correlation post-surgery is unclear.
  • Understanding this relationship can improve registry data interpretation and clinical decision-making.

Purpose of the Study:

  • To investigate the correlation between subjective patient-reported outcome measures (PROMs) and objective clinical findings after knee cartilage repair surgery.
  • To determine if PROMs accurately reflect objective functional recovery in patients undergoing cartilage repair.

Main Methods:

  • Analysis of 52 patients from the German Cartilage Registry (KnorpelRegister DGOU) who underwent knee cartilage repair.
  • Standardized follow-up examinations including PROMs and objective findings using a modified International Cartilage Repair Society (ICRS) score.
  • Spearman's rank correlation coefficient used to assess the relationship between subjective scores and objective ICRS scores.

Main Results:

  • Moderate, significant negative correlations found between objective ICRS score and Knee Injury and Osteoarthritis Outcome Score (KOOS) Symptoms (ρ = -0.420, p = 0.005) and KOOS Quality of Life (QoL) (ρ = -0.377, p = 0.013).
  • Moderate, significant negative correlation also observed between objective ICRS score and the subjective International Knee Documentation Committee (IKDC) score (ρ = -0.305, p = 0.028).
  • No significant correlations were found between the objective ICRS score and other KOOS subscales (Pain, Activities of Daily Living, Sport).

Conclusions:

  • PROMs offer valuable insights into perceived patient outcomes after knee cartilage repair.
  • PROMs do not fully reflect objective functional recovery, highlighting the need for combined clinical assessments.
  • Integrating subjective and objective measures enhances the interpretation of outcomes in knee cartilage repair registries.