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Predictive Value of Adiponectin for Long-Term MACEs in Non-Diabetic STEMI Patients
Xhevdet Krasniqi1,2, Josip Vincelj3, Ibadete Bytyçi1,2
1Department of Internal Medicine, Medical Faculty, University of Prishtina "Hasan Prishtina", 10000 Prishtina, Kosovo.
Low adiponectin levels predict major adverse cardiac events (MACEs) after ST-segment elevation myocardial infarction (STEMI). A threshold of 1.8 ng/mL identified patients at higher risk for MACEs and heart failure.
Area of Science:
- Cardiology
- Biochemistry
- Clinical Medicine
Background:
- Decreased adiponectin levels are linked to adverse left ventricular remodeling and major adverse cardiac events (MACEs).
- This study investigates the long-term MACEs following ST-segment elevation myocardial infarction (STEMI) in relation to adiponectin levels.
Purpose of the Study:
- To evaluate the association between serum adiponectin levels and long-term MACEs in STEMI patients.
- To identify a potential cut-off value of adiponectin for predicting MACEs post-STEMI.
Main Methods:
- Prospective study of 73 STEMI patients.
- Measurement of serum adiponectin and other laboratory parameters.
- Assessment of myocardial revascularization, echocardiography, and MACEs over time.
Main Results:
- 24 patients (32.87%) experienced MACEs, with 19 in the low adiponectin group (≤1.8 ng/mL).
- Heart failure was significantly more prevalent in the low adiponectin group (19.17% vs 4.1%).
- Kaplan-Meier analysis and logistic regression confirmed adiponectin as a significant predictor of MACEs (p=0.011).
Conclusions:
- Serum adiponectin levels are significantly associated with MACEs in STEMI survivors.
- An adiponectin cut-off value of 1.8 ng/mL during hospitalization effectively identifies patients at risk for MACEs.
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