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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Three-Dimensional Printing in Paediatrics: Innovative Technology for Manufacturing Patient-Centred Drug Delivery

Nadine Couți1, Sonia Iurian1, Alina Porfire1

  • 1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 41 V. Babes Street, 400012 Cluj-Napoca, Romania.

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Summary
This summary is machine-generated.

Three-dimensional (3D) printing offers a revolutionary solution for pediatric drug development, addressing unique needs unmet by traditional methods. This technology enhances drug formulation, palatability, and patient acceptance for children.

Keywords:
chewable dosage formschild-appropriate medicinesdirect powder extrusionfused deposition modellingpaediatric formulationsprintletssemi-solid extrusion

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Area of Science:

  • Pharmaceutical Technology
  • Pediatric Drug Delivery
  • Additive Manufacturing

Background:

  • Children have unique drug requirements often unmet by conventional pharmaceutical technologies.
  • Traditional dosage forms present challenges including inaccurate dosing, excipient safety concerns, and poor taste masking.
  • Three-dimensional (3D) printing, or additive manufacturing, presents a promising avenue to overcome these limitations in pediatric drug development.

Purpose of the Study:

  • To explore the application and potential of 3D printing technologies in creating tailored drug formulations for pediatric patients.
  • To review various 3D printing techniques and their suitability for pediatric oral dosage forms.
  • To highlight the advantages of 3D printing, such as improved dose flexibility, enhanced palatability, and patient-friendly designs.

Main Methods:

  • Review of existing literature on 3D printing techniques applied to pediatric drug formulations.
  • Identification and discussion of key 3D printing methods, including hot-melt extrusion (HME) with fused deposition modelling (FDM), direct powder extrusion (DPE), and semisolid extrusion (SSE).
  • Exploration of less common but relevant techniques like Selective Laser Sintering (SLS) and binder-jet (BJ) 3D printing.

Main Results:

  • 3D printing enables the creation of diverse pediatric oral formulations like miniaturized tablets, chewable tablets, and orodispersible films.
  • Key formulation aspects addressed include dose accuracy, excipient safety, taste-masking of bitter drugs, and appealing designs for children.
  • Essential medicines for pediatric use, often lacking flexible and age-appropriate commercial options, can be effectively produced using 3D printing.

Conclusions:

  • 3D printing holds significant potential to revolutionize pediatric drug development by providing customized, patient-centric dosage forms.
  • While technical and in vitro data are substantial, clinical translation and research into the efficacy of 3D-printed pediatric dosage forms remain limited.
  • Further clinical studies are essential to validate the efficacy and widespread adoption of 3D-printed medications in pediatric practice.