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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: May 11, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
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Nanoparticle-Based Targeted Drug Delivery Methods for Heart-Specific Distribution in Cardiovascular Therapy.

Toshihiko Tashima1

  • 1Tashima Laboratories of Arts and Sciences, 1239-5 Toriyama-cho, Kohoku-ku, Yokohama 222-0035, Kanagawa, Japan.

Pharmaceutics
|November 27, 2025
PubMed
Summary

Developing non-invasive pharmaceutical delivery for cardiovascular diseases is crucial. This review explores nanoparticle strategies for targeted cardiac drug delivery, addressing unmet medical needs in heart failure and myocardial infarction.

Keywords:
cardiovascular diseasesheart-targeted drug deliverynanoparticle-mediated deliveryreceptor-mediated endocytosis/transcytosis

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Area of Science:

  • Cardiovascular Medicine
  • Nanotechnology
  • Pharmacology

Background:

  • Cardiovascular diseases are a leading global cause of death, often requiring invasive surgeries.
  • Current treatments for cardiovascular diseases focus on peripheral tissues, with limited direct cardiac drug delivery.
  • Significant unmet medical needs exist for effective, non-invasive cardiovascular therapies.

Purpose of the Study:

  • To review emerging strategies for non-invasive cardiac drug delivery.
  • To explore the potential of nanoparticle-based systems for targeted myocardial delivery.
  • To address challenges in delivering therapeutics for conditions like congestive heart failure and myocardial infarction.

Main Methods:

  • Perspective review of current literature and emerging strategies.
  • Focus on nanoparticle-based delivery systems.
  • Discussion of receptor-mediated endocytosis and transcytosis mechanisms for cardiac targeting.

Main Results:

  • Non-invasive strategies, particularly nanoparticle-based systems, show promise for cardiac drug delivery.
  • Targeted delivery to the myocardium remains a significant challenge.
  • Existing nanoparticle strategies for brain and cancer targeting may be adaptable for cardiac applications.

Conclusions:

  • Nanoparticle-based drug delivery offers a promising avenue for non-invasive cardiac therapeutics.
  • Further research is needed to optimize these systems for effective myocardial targeting.
  • Advancing non-invasive cardiac drug delivery is critical for managing cardiovascular diseases.