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Updated: Jan 10, 2026
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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Advances in Oral Drug Delivery Systems for Natural Polyunsaturated Fatty Acids: Enhancing Bioavailability and
Matheus Felipe Zazula1, Roberta Pozzan2, Guilherme Anacleto Dos Reis3
1Laboratório de Plasticidade Morfofuncional, Departamento de Biologia Celular, Setor de Ciências Biológicas, Centro Politécnico, Universidade Federal do Paraná, Curitiba 81531-908, Paraná, Brazil.
Pharmaceutics
|November 27, 2025
Summary
Innovative drug delivery systems enhance omega-3 and omega-6 fatty acids oral administration. These advanced methods improve stability, absorption, and clinical efficacy for essential fatty acids.
Area of Science:
- Nutritional Science
- Pharmacology
- Biotechnology
Background:
- Omega-3 and omega-6 fatty acids are vital for health, used in treating cardiovascular diseases, inflammation, and metabolic disorders.
- Oral administration of these polyunsaturated fatty acids is hindered by low solubility, oxidation, and poor bioavailability.
- Current delivery methods limit the full therapeutic potential of essential fatty acids.
Purpose of the Study:
- To review recent advancements in oral drug delivery systems for omega-3 and omega-6 fatty acids.
- To analyze how novel technologies improve the stability, absorption, and clinical performance of these essential fatty acids.
- To discuss natural sources, extraction, purification, and metabolism challenges of omega-3 and omega-6.
Main Methods:
- Comprehensive literature search (2015-2025) in PubMed, Scopus, and Web of Science.
- Narrative review focusing on innovative delivery technologies.
- Comparative analysis of conventional versus modern delivery strategies.
Main Results:
- Nanoemulsions, liposomes, microencapsulation, and solid lipid nanoparticles (SLNs/NLCs) show promise in enhancing fatty acid delivery.
- These systems improve stability, bioavailability, and therapeutic outcomes compared to conventional methods.
- Emerging approaches offer optimized utilization of omega-3 and omega-6 in the body.
Conclusions:
- Advanced oral delivery systems can overcome limitations of essential fatty acids.
- These technologies have the potential to revolutionize fatty acid administration in medicine and nutrition.
- Future research and regulatory considerations are crucial for widespread adoption.
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