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  1. Home
  3. Age-stratified Clinical And Microbiological Profiles In Pediatric Infectious Disease Admissions: Implications For Risk Prediction And Antimicrobial Stewardship.
  1. Home
  3. Age-stratified Clinical And Microbiological Profiles In Pediatric Infectious Disease Admissions: Implications For Risk Prediction And Antimicrobial Stewardship.

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Age-Stratified Clinical and Microbiological Profiles in Pediatric Infectious Disease Admissions: Implications for

Cristina Elena Singer1, Elena Catalina Bica1, Simina Gaman2

  • 1Department of Mother and Baby, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Pharmaceutics
|November 27, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Escherichia coliKlebsiella speciesage-stratified analysisantimicrobial stewardshipclinical outcomeshospitalization outcomesmethicillin-resistant Staphylococcus aureusmicrobiological profilespediatric infectious diseasesrisk prediction

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Pediatric infectious disease admissions vary. A composite risk score identified high-risk children needing targeted care, improving antimicrobial stewardship and patient outcomes.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Pediatric infectious-disease admissions are common but present diverse clinical and microbiological patterns.
  • Understanding these patterns is crucial for effective antimicrobial stewardship.

Purpose of the Study:

  • To characterize clinical, microbiological, and therapeutic patterns in pediatric infectious-disease admissions.
  • To identify high-risk pediatric subgroups for targeted interventions and improved antimicrobial stewardship.

Main Methods:

  • An observational cohort study of 136 children stratified by age.
  • Data collected included symptoms, diagnoses, culture results, pathogens, antibiotic therapy, and outcomes.
  • A composite risk score was developed integrating age, clinical, and microbiological parameters.

Main Results:

  • Overall outcomes were favorable, with low intensive care unit (ICU) transfer (8.8%) and mortality (0.7%).
  • Pneumonia was the leading diagnosis; *Escherichia coli* and *Klebsiella* species were predominant pathogens.
  • A composite risk score effectively identified a high-risk subgroup with increased ICU transfer and prolonged length of stay (LOS).

Conclusions:

  • While overall outcomes are good, risk stratification is essential in pediatric infectious diseases.
  • An age-stratified, multifactorial assessment aids in identifying at-risk pediatric patients.
  • Findings support targeted monitoring and age-aware empiric therapy aligned with antimicrobial stewardship goals.